This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
Jin, Pahuja, Wickliffe, Gorur, Baumgärtel, Schekman, Rape: "Ubiquitin-dependent regulation of COPII coat size and function." in: Nature, Vol. 482, Issue 7386, pp. 495-500, (2012) (PubMed).
Suzuki, Yamashita, Shirota, Sakakibara, Chiba, Mizushima-Sugano, Nakai, Sugano: "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions." in: Genome research, Vol. 14, Issue 9, pp. 1711-8, (2004) (PubMed).
Aliases for KLHL13 抗体
Kelch-like protein 13 (klh13) 抗体 kelch-like 13 (Klhl13) 抗体 kelch like family member 13 (KLHL13) 抗体 kelch like family member 9 (KLHL9) 抗体 kelch-like family member 13 (Klhl13) 抗体 1200009K10Rik 抗体 AI451128 抗体 Bklhd2 抗体 BKLHD2 抗体 D130072F20Rik 抗体 mKIAA1309 抗体