KLHL12 抗体
(Kelch-Like 12 (Drosophila) (KLHL12))
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (By similarity).
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50 results
KLHL12
适用: 人, 小鼠, 大鼠
WB, ELISA, IHC, IF, ICC, FACS
宿主: 兔
Polyclonal
unconjugated
Latest Publications for our KLHL12 抗体
: "COPII-coated membranes function as transport carriers of intracellular procollagen I." in: The Journal of cell biology, Vol. 216, Issue 6, pp. 1745-1759, (2017) (PubMed).: "Ubiquitin-dependent regulation of COPII coat size and function." in: Nature, Vol. 482, Issue 7386, pp. 495-500, (2012) (PubMed).
Aliases for KLHL12 抗体
Ski2 like RNA helicase (SKIV2L) 抗体kelch like family member 12 L homeolog (klhl12.L) 抗体
kelch like family member 12 (KLHL12) 抗体
kelch-like family member 12 (klhl12) 抗体
kelch-like 12 (Klhl12) 抗体
kelch-like family member 12 (Klhl12) 抗体
C3ip1 抗体
C3IP1 抗体
DKIR 抗体
hDKIR 抗体
wu:fi60g03 抗体
zgc:92570 抗体
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