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PRTN3 ELISA 试剂盒

PRTN3 Colorimetric Competition ELISA
产品编号 ABIN996889
发货至: 中国
  • 抗原 See all PRTN3 ELISA试剂盒
    PRTN3 (Proteinase 3 (PRTN3))
    检测方法
    Colorimetric
    实验类型
    Competition ELISA
    应用范围
    ELISA
    原理
    Proteinase-3 (PR-3) Enzyme-Linked Immunosorbent Assay (ELISA) is intended for the detection and semiquantitative determination of antibodies to PR-3 in human sera. The assay is to be used to detect antibodies in a single serum specimen. The results of the assay are to be used as an aid in the diagnosis of Wegener’s granulomatosis
    Analytical Method
    Semi-Quantitative
    特异性
    95.6%
    灵敏度
    98.2%
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  • 样本量
    10 μL
    实验时间
    1 - 2 h
    板类型
    Pre-coated
    限制
    仅限研究用
  • 储存条件
    4 °C
    有效期
    12 months
  • 抗原 See all PRTN3 ELISA试剂盒
    PRTN3 (Proteinase 3 (PRTN3))
    别名
    PR3 (c-ANCA) (PRTN3 产品)
    别名
    ela2 ELISA Kit, MGC132250 ELISA Kit, ACPA ELISA Kit, AGP7 ELISA Kit, C-ANCA ELISA Kit, CANCA ELISA Kit, MBN ELISA Kit, MBT ELISA Kit, NP-4 ELISA Kit, NP4 ELISA Kit, P29 ELISA Kit, PR-3 ELISA Kit, PR3 ELISA Kit, mPR3 ELISA Kit, proteinase 3 L homeolog ELISA Kit, proteinase 3 ELISA Kit, prtn3.L ELISA Kit, PRTN3 ELISA Kit, Prtn3 ELISA Kit
    背景
    Proteinase-3 is a lysosomal enzyme that can be found in human neutrophils. There are two subsets of autoantibodies to human neutrophils: c- ANCA and p-ANCA. The first subtype, c-ANCA, shows cytoplasmic staining by IFA and is diagnostic for Wegener's granulomatosis. The major antigen responsible for the c-ANCA staining is Proteinase-3. The second subtype, p-ANCA, shows perinuclear staining by IFA. The major antigen responsible for the p-ANCA response has been shown to be myeloperoxidase. The ANCA staining patterns are obtained using ethanol-fixed human neutrophils. Anti- PR-3 autoantibodies have been associated with Wegener's granulomatosis but less often with microscopic polyangiitis. Other antigen specificity's (CAP 57) can be responsible for the c-ANCA pattern. These antigens are generally not diagnostic for PR-3 associated vaculitus diseases.
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