PRTN3 ELISA 试剂盒
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Quick Overview for PRTN3 ELISA 试剂盒 (ABIN996889)
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See all PRTN3 ELISA试剂盒检测方法
实验类型
应用范围
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原理
- Proteinase-3 (PR-3) Enzyme-Linked Immunosorbent Assay (ELISA) is intended for the detection and semiquantitative determination of antibodies to PR-3 in human sera. The assay is to be used to detect antibodies in a single serum specimen. The results of the assay are to be used as an aid in the diagnosis of Wegener’s granulomatosis
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Analytical Method
- Semi-Quantitative
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特异性
- 95.6%
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灵敏度
- 98.2%
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Proteinase 3 (PRTN3) ELISA Kit
PRTN3 适用: 人 Colorimetric Sandwich ELISA 0.78 ng/mL - 50 ng/mL Plasma, Serum, Tissue Homogenate, Urine
Proteinase 3 (PRTN3) ELISA KitPRTN3 适用: 人 Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Plasma, Serum
Proteinase 3 (PRTN3) ELISA KitPRTN3 适用: 大鼠 Colorimetric Sandwich ELISA 3.12 ng/mL - 200 ng/mL Plasma, Serum
Proteinase 3 (PRTN3) ELISA KitPRTN3 适用: 小鼠 Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Plasma, Serum, Tissue Homogenate
Proteinase 3 (PRTN3) ELISA KitPRTN3 适用: 人 Colorimetric Sandwich ELISA 0.16 ng/mL - 10 ng/mL Cell Culture Supernatant, Plasma, Serum
Proteinase 3 (PRTN3) ELISA KitPRTN3 适用: 人 Colorimetric Sandwich ELISA 0.156 ng/mL - 10 ng/mL Plasma, Serum, Tissue Homogenate
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样本量
- 10 μL
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实验时间
- 1 - 2 h
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板类型
- Pre-coated
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限制
- 仅限研究用
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储存条件
- 4 °C
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有效期
- 12 months
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- PRTN3 (Proteinase 3 (PRTN3))
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别名
- PR3 (c-ANCA)
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背景
- Proteinase-3 is a lysosomal enzyme that can be found in human neutrophils. There are two subsets of autoantibodies to human neutrophils: c- ANCA and p-ANCA. The first subtype, c-ANCA, shows cytoplasmic staining by IFA and is diagnostic for Wegener's granulomatosis. The major antigen responsible for the c-ANCA staining is Proteinase-3. The second subtype, p-ANCA, shows perinuclear staining by IFA. The major antigen responsible for the p-ANCA response has been shown to be myeloperoxidase. The ANCA staining patterns are obtained using ethanol-fixed human neutrophils. Anti- PR-3 autoantibodies have been associated with Wegener's granulomatosis but less often with microscopic polyangiitis. Other antigen specificity's (CAP 57) can be responsible for the c-ANCA pattern. These antigens are generally not diagnostic for PR-3 associated vaculitus diseases.
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