PGLYRP1 ELISA 试剂盒
Quick Overview for PGLYRP1 ELISA 试剂盒 (ABIN5510755)
抗原
See all PGLYRP1 ELISA试剂盒抗原表位
适用
检测方法
实验类型
应用范围
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原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse PGLYRP1
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品牌
- PicoKine™
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Analytical Method
- Quantitative
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特异性
- Expression system for standard: NSO, Immunogen sequence: F19-E182
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交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
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产品特性
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Tissue Specificity: Strongly expressed in spleen and lung. Also detected in brain and thymus. In the lung, expressed in the intraalveolar space, in the brain, expressed in the Purkinje cells of the cerebellum and in certain layers of neurons in the hippocampus. Also detected in cells filling the space within the intestinal villus.
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Peptidoglycan Recognition Protein 1 (PGLYRP1) ELISA Kit
PGLYRP1 适用: 人 Colorimetric Sandwich ELISA 0.31 ng/mL - 20 ng/mL Cell Culture Supernatant, Plasma, Serum
Peptidoglycan Recognition Protein 1 (PGLYRP1) ELISA KitPGLYRP1 适用: 人 Colorimetric Sandwich ELISA 0.78 ng/mL - 50 ng/mL Plasma, Serum, Tissue Homogenate
Peptidoglycan Recognition Protein 1 (PGLYRP1) ELISA KitPGLYRP1 适用: 小鼠 Colorimetric Sandwich ELISA 15.6 pg/mL - 1000 pg/mL Plasma, Serum, Tissue Homogenate
Peptidoglycan Recognition Protein 1 (PGLYRP1) ELISA KitPGLYRP1 适用: 人 Colorimetric Sandwich ELISA 0.312 ng/mL - 20 ng/mL Cell Lysate, Plasma, Serum
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板类型
- Pre-coated
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限制
- 仅限研究用
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
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有效期
- 12 months
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- PGLYRP1 (Peptidoglycan Recognition Protein 1 (PGLYRP1))
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别名
- Pglyrp1
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背景
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Protein Function: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria. Involved in innate immunity. May function in intracellular killing of bacteria. The soluble form triggers apoptosis in vitro.
Background: Peptidoglycan recognition protein 1, also known as TAG7, is a protein that in humans is encoded by the PGLYRP1 gene. The PGLYRP1 gene is highly expressed in bone marrow, circulating Polymorphonuclear leukocytes (PMLs), and in the corneal epithelium. The PGLYRP1 protein is primarily found in the granules of PMLs. The PGLYRP1 protein plays an important role in the innate immune response. It is bactericidal against gram-positive bacteria such as S. aureus, S. epidermidis, and L. monocytogenes and generally has proinflammatory effects, inducing TNF-a and IFN-g in many tissues. PGLYRP-1 is also known to form a cytotoxic complex with HSP-70, suggesting it may also have a role in anti-cancer defense. As a pathogen recognition protein with antimicrobial properties, PGLYRP-1 is suspected to play an important role in maintaining the gut microbial flora.
Synonyms: Peptidoglycan recognition protein 1, Cytokine tag7, Peptidoglycan recognition protein short, PGRP-S, Pglyrp1, Pglyrp, Pgrp, Pgrps, Tag7,
Full Gene Name: peptidoglycan recognition protein 1
Cellular Localisation: Cytoplasm -
UniProt
- O88593
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途径
- Activation of Innate immune Response
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