ULBP2 ELISA 试剂盒
Quick Overview for ULBP2 ELISA 试剂盒 (ABIN5510744)
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适用
检测方法
实验类型
应用范围
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原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human ULBP2
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品牌
- PicoKine™
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Analytical Method
- Quantitative
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特异性
- Expression system for standard: NSO, Immunogen sequence: G26-S216
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交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
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产品特性
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Tissue Specificity: Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. .
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UL16 Binding Protein 2 (ULBP2) ELISA Kit
ULBP2 适用: 人 Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Plasma, Serum, Tissue Homogenate
UL16 Binding Protein 2 (ULBP2) ELISA KitULBP2 适用: 人 Colorimetric Sandwich ELISA 62.5-4000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
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板类型
- Pre-coated
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限制
- 仅限研究用
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
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有效期
- 12 months
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- ULBP2 (UL16 Binding Protein 2 (ULBP2))
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别名
- ULBP2
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背景
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Protein Function: Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. .
Background: UL16 binding protein 2 (ULBP2) is a cell surface glycoprotein encoded by ULBP2 gene located on the chromosome 6. This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells.
Synonyms: NKG2D ligand 2,N2DL-2,NKG2DL2,ALCAN-alpha,Retinoic acid early transcript 1H,UL16-binding protein 2,ULBP2,N2DL2, RAET1H,UNQ463/PRO791,
Full Gene Name: NKG2D ligand 2
Cellular Localisation: Cell membrane, Lipid-anchor, GPI-anchor. Secreted. -
UniProt
- Q9BZM5
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