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- 抗原 See all RSPO1 ELISA试剂盒
- RSPO1 (R-Spondin 1 (RSPO1))
- 抗原表位
- AA 21-263
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适用
- 人
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 应用范围
- ELISA
- 原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human R-Spondin-1
- 品牌
- PicoKine™
- Analytical Method
- Quantitative
- 特异性
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Expression system for standard: NSO
Immunogen sequence: S21-A263 - 交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
- 产品特性
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Tissue Specificity: Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. .
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R-Spondin 1 (RSPO1) ELISA Kit
RSPO1 适用: 人 Colorimetric Sandwich ELISA 15.6 pg/mL - 1000 pg/mL Plasma, Serum, Tissue Homogenate
R-Spondin 1 (RSPO1) ELISA KitRSPO1 适用: 小鼠 Colorimetric Sandwich ELISA 6.25 pg/mL - 400 pg/mL Plasma, Serum, Tissue Homogenate
R-Spondin 1 (RSPO1) ELISA KitHigh Sensitivity RSPO1 适用: 小鼠 Colorimetric Sandwich ELISA 15.6 pg/mL - 1000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
R-Spondin 1 (RSPO1) ELISA KitRSPO1 适用: 小鼠 Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Cell Culture Supernatant, Cell Lysate, Tissue Homogenate
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- 板类型
- Pre-coated
- 限制
- 仅限研究用
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- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- 有效期
- 12 months
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- 抗原 See all RSPO1 ELISA试剂盒
- RSPO1 (R-Spondin 1 (RSPO1))
- 别名
- RSPO1 (RSPO1 产品)
- 别名
- RGD1565558 ELISA Kit, CRISTIN3 ELISA Kit, RSPO ELISA Kit, R-spondin ELISA Kit, Rspondin ELISA Kit, wu:fj81e05 ELISA Kit, zgc:92153 ELISA Kit, R-spondin 1 ELISA Kit, Rspo1 ELISA Kit, RSPO1 ELISA Kit, LOC100049655 ELISA Kit, rspo1 ELISA Kit
- 背景
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Protein Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. .
Background: R-spondin-1 is a secreted protein that in humans is encoded by the Rspo1 gene. It is mapped to chromosome 1p34. This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy- induced adverse effects. Alternative splicing results in multiple transcript variants.
Synonyms: R-spondin-1,Roof plate-specific spondin-1,hRspo1,RSPO1,
Full Gene Name: R-spondin-1
Cellular Localisation: Secreted . Nucleus . Seems to mainly localize to nucleoli.. - UniProt
- Q2MKA7
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