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- 抗原 See all R-Spondin 3 (RSPO3) ELISA试剂盒
- R-Spondin 3 (RSPO3)
- 抗原表位
- AA 22-272
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适用
- 人
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 应用范围
- ELISA
- 原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human R-Spondin-3
- 品牌
- PicoKine™
- Analytical Method
- Quantitative
- 特异性
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Expression system for standard: NSO
Immunogen sequence: Q22-H272 - 交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
- 产品特性
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Tissue Specificity: Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node (PubMed:12463421). Highly expressed in endothelial cells (PubMed:26766444). .
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R-Spondin 3 (RSPO3) ELISA Kit
RSPO3 适用: 小鼠 Colorimetric Sandwich ELISA 4.7 pg/mL - 300 pg/mL Plasma, Serum, Tissue Homogenate
R-Spondin 3 (RSPO3) ELISA KitRSPO3 适用: 人 Colorimetric Sandwich ELISA 0.31 ng/mL - 20 ng/mL Plasma, Serum, Tissue Homogenate
R-Spondin 3 (RSPO3) ELISA KitRSPO3 适用: 小鼠 AA 22-277 Colorimetric Sandwich ELISA
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- 板类型
- Pre-coated
- 限制
- 仅限研究用
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- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- 有效期
- 12 months
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- 抗原 See all R-Spondin 3 (RSPO3) ELISA试剂盒
- R-Spondin 3 (RSPO3)
- 别名
- RSPO3 (RSPO3 产品)
- 别名
- pwtsr ELISA Kit, thsd2 ELISA Kit, cristin1 ELISA Kit, CRISTIN1 ELISA Kit, PWTSR ELISA Kit, THSD2 ELISA Kit, RGD1563246 ELISA Kit, 2810459H04Rik ELISA Kit, AW742308 ELISA Kit, Cristin1 ELISA Kit, Thsd2 ELISA Kit, R-spondin 3 ELISA Kit, rspo3 ELISA Kit, RSPO3 ELISA Kit, Rspo3 ELISA Kit
- 背景
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Protein Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta- catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity). .
Background: R-spondin-3 is a protein that in humans is encoded by the RSPO3 gene. This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development.
Synonyms: R-spondin-3,Protein with TSP type-1 repeat,hPWTSR,Roof plate-specific spondin-3,hRspo3,Thrombospondin type-1 domain-containing protein 2,RSPO3,PWTSR, THSD2,
Full Gene Name: R-spondin-3
Cellular Localisation: Secreted. - UniProt
- Q9BXY4
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