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Quick Overview for SPHK1 ELISA 试剂盒 (ABIN5510666)
抗原
See all SPHK1 ELISA试剂盒抗原表位
适用
检测方法
实验类型
应用范围
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原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human SPHK1
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Analytical Method
- Quantitative
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特异性
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Expression system for standard: NSO
Immunogen sequence: M1-L384 -
交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
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产品特性
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Tissue Specificity: Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. .
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Sphingosine Kinase 1 (SPHK1) ELISA Kit
SPHK1 适用: 人 Colorimetric Sandwich ELISA 0.31 ng/mL - 20 ng/mL Cell Lysate, Tissue Homogenate
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板类型
- Pre-coated
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限制
- 仅限研究用
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
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有效期
- 12 months
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- SPHK1 (Sphingosine Kinase 1 (SPHK1))
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别名
- SPHK1
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背景
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Protein Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. .
Background: Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene. The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1- phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: Sphingosine kinase 1,SK 1,SPK 1,2.7.1.91,SPHK1,SPHK, SPK,
Full Gene Name: Sphingosine kinase 1
Cellular Localisation: Cytoplasm. Nucleus. Cell membrane. Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner. -
UniProt
- Q9NYA1
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途径
- VEGF Signaling
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