MPL ELISA 试剂盒
Quick Overview for MPL ELISA 试剂盒 (ABIN5510636)
抗原
See all MPL ELISA试剂盒抗原表位
适用
检测方法
实验类型
应用范围
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原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse TPOR/MPL
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品牌
- PicoKine™
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Analytical Method
- Quantitative
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特异性
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Expression system for standard: NSO
Immunogen sequence: Q26-W482 -
交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
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Myeloproliferative Leukemia Virus Oncogene (MPL) ELISA Kit
MPL 适用: 人 Colorimetric Sandwich ELISA 0.31 ng/mL - 20 ng/mL Cell Lysate, Tissue Homogenate
Myeloproliferative Leukemia Virus Oncogene (MPL) ELISA KitMPL 适用: 大鼠 Colorimetric Sandwich ELISA 0.78 ng/mL - 50 ng/mL Plasma, Serum
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板类型
- Pre-coated
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限制
- 仅限研究用
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
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有效期
- 12 months
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- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
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别名
- Mpl
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背景
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Protein Function: Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
Background: The thrombopoietin receptor (TPOR), also known as CD110, is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene. The human MPL gene is mapped to chromosome 1p34. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
Synonyms: Thrombopoietin receptor,TPO-R,Myeloproliferative leukemia protein,Proto-oncogene c-Mpl,CD110,Mpl,Tpor,
Full Gene Name: Thrombopoietin receptor
Cellular Localisation: Cell membrane, Single-pass type I membrane protein . Golgi apparatus . Cell surface. -
UniProt
- Q08351
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途径
- JAK/STAT Signaling
抗原 See all MPL ELISA试剂盒
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