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Quick Overview for CD28 ELISA 试剂盒 (ABIN5510635)
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适用
检测方法
实验类型
应用范围
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原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human CD28
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Analytical Method
- Quantitative
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特异性
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Expression system for standard: NSO
Immunogen sequence: N19-P152 -
交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
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产品特性
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Tissue Specificity: Expressed in T-cells and plasma cells, but not in less mature B-cells.
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CD28 (CD28) ELISA Kit
CD28 适用: 人 Colorimetric Sandwich ELISA 0.625 ng/mL - 40 ng/mL Plasma, Serum, Tissue Homogenate
CD28 (CD28) ELISA KitCD28 适用: 小鼠 Colorimetric Sandwich ELISA 0.156 ng/mL - 10 ng/mL Plasma, Serum, Tissue Homogenate
CD28 (CD28) ELISA KitCD28 适用: 大鼠 Colorimetric Sandwich ELISA 0.313 ng/mL - 20 ng/mL Plasma, Serum, Tissue Homogenate
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板类型
- Pre-coated
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限制
- 仅限研究用
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
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有效期
- 12 months
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- CD28
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别名
- CD28
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背景
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Protein Function: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). .
Background: CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co- stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular). The CD28 gene is mapped to 2q33-q34. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily.
Synonyms: T-cell-specific surface glycoprotein CD28,TP44,CD28,CD28,
Full Gene Name: T-cell-specific surface glycoprotein CD28
Cellular Localisation: Membrane, Single-pass type I membrane protein. -
UniProt
- P10747
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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