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MMP8 ELISA 试剂盒

This 小鼠 MMP8 ELISA Kit is a Colorimetric ELISA Kit designed to quantify 小鼠 MMP8.
产品编号 ABIN5510633
发货至: 中国

Quick Overview for MMP8 ELISA 试剂盒 (ABIN5510633)

抗原

See all MMP8 ELISA试剂盒
MMP8 (Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8))

抗原表位

AA 21-465

适用

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小鼠

检测方法

Colorimetric

实验类型

Sandwich ELISA

应用范围

ELISA
  • 原理

    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse MMP-8

    品牌

    PicoKine™

    Analytical Method

    Quantitative

    特异性

    Expression system for standard: NSO
    Immunogen sequence: F21-S465

    交叉反应 (详细)

    There is no detectable cross-reactivity with other relevant proteins.

    产品特性

    Tissue Specificity: Neutrophils. Expressed in uterus. Low levels in kidney and muscle.

  • 板类型

    Pre-coated

    限制

    仅限研究用
  • 储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

    有效期

    12 months
  • 抗原 See all MMP8 ELISA试剂盒

    MMP8 (Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8))

    别名

    Mmp8

    背景

    Protein Function: Can degrade fibrillar type I, II, and III collagens. May play a role in the degradation of collagen fibers during uterine involution.

    Background: Matrix metalloproteinase 8 (MMP8) also called neutrophil collagenase. Neutrophil collagenase, a member of the family of matrix metalloproteinases, is distinct from the collagenase of skin fibroblasts and synovial cells in substrate specificity and immunologic crossreactivity. MMP8, an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes, is expressed by leukocytes and chorionic cytotrophoblast cells. The human neutrophil collagenase (HNC) cDNA clone has been sequenced and shown to encode a 467-residue protein. Neutrophil collagenase has been found to possess 57 % identity with the deduced protein sequence for fibroblast collagenase with 72 % chemical similarity. Certain regions of the molecule, including the putative zinc-binding region, are highly conserved. When compared with the published sequence for fibroblast collagenase, neutrophil collagenase contains four additional sites for glycosylation.

    Synonyms: Neutrophil collagenase,3.4.24.34,Collagenase 2,Matrix metalloproteinase-8,MMP-8,Mmp8,

    Full Gene Name: Neutrophil collagenase

    Cellular Localisation: Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Stored in intracellular granules and released during inflammatory conditions.

    UniProt

    O70138
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