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N-Cadherin ELISA 试剂盒

This 兔 N-Cadherin ELISA Kit specifically detects N-Cadherin .
产品编号 ABIN5510582
发货至: 中国
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Quick Overview for N-Cadherin ELISA 试剂盒 (ABIN5510582)

抗原

See all N-Cadherin (CDH2) ELISA试剂盒
N-Cadherin (CDH2) (Cadherin 2 (CDH2))

抗原表位

AA 160-724

适用

  • 7
  • 6
  • 6
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1

检测方法

Colorimetric

实验类型

Sandwich ELISA

应用范围

ELISA
  • 原理

    Sandwich High Sensitivity ELISA kit for Quantitative Detection of rabbit Cadherin-2/N-Cadherin

    Analytical Method

    Quantitative

    特异性

    Expression system for standard: NSO
    Immunogen sequence: D160-A724

    交叉反应 (详细)

    There is no detectable cross-reactivity with other relevant proteins.
  • 板类型

    Pre-coated

    限制

    仅限研究用
  • 储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

    有效期

    12 months
  • 抗原 See all N-Cadherin (CDH2) ELISA试剂盒

    N-Cadherin (CDH2) (Cadherin 2 (CDH2))

    别名

    CDH2

    背景

    Protein Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity). .

    Background: Cadherin-2(CDH2), also known as neural cadherin(NCAD), is a protein that in humans is encoded by the CDH2 gene. It is a classical cadherin from the cadherin superfamily. This gene is mapped to 18q12.1. Cadherin-2 is expressed in the brain, skeletal and cardiac muscle. Cadherin-2 is commonly found in cancer cells and provides a mechanism for transendothelial migration. It is a calcium dependent cell-cell adhesion glycoprotein comprising five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

    Synonyms: Cadherin-2,CDw325,Neural cadherin,N-cadherin,CD325,CDH2,CDHN, NCAD,

    Full Gene Name: Cadherin-2

    Cellular Localisation: Cell membrane, Single-pass type I membrane protein.

    UniProt

    P19022

    途径

    Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane
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