Leptin ELISA 试剂盒
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北京 101111
Quick Overview for Leptin ELISA 试剂盒 (ABIN5068384)
抗原
See all Leptin (LEP) ELISA试剂盒适用
检测方法
应用范围
样品类型
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灵敏度
- 0.5 ng/mL
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产品特性
- Leptin, Serum, Human, ELISA Kit (Ob, Obese Protein, Obesity Factor)
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组件
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- Microwell Strip Plate, 1x96wells
- Standard, 0ng/ml, 1x10ml
- Standard, 1ng/ml, 1x500ul
- Standard, 5ng/ml, 1x500ul
- Standard, 10ng/ml, 1x500ul
- Standard, 20ng/ml, 1x500ul
- Standard, 50ng/ml, 1x500ul
- Standard, 100ng/ml, 1x500ul
- Low Control, 1x500ul
- 0: High Control, 1x500ul
- 1: AB (Biotin), 1x10ml
- 2: Streptavidin (HRP) 50X, 1x400ul
- 3: Assay Buffer, 1x20ml
- 4: Wash Buffer, 10X, 1x50ml
- 5: TMB, 1x16ml
- 6: Stop Solution, 1x6ml
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限制
- 仅限研究用
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储存条件
- 4 °C
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储存方法
- 4°C
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- Leptin (LEP)
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别名
- Leptin
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背景
- Obesity, a common nutritional disorder, is associated with diabetes, hypertension, hyperlipidemia, cancer and many other health related problems. At least five genes, Obese (ob), diabetes (db), fat (fat), agouti yellow (Ay), and tubby (tub) have been linked to obesity. Recently, Ob genes (mouse and human) have been cloned. Obese gene encodes an adipocyte-tissue derived secreted Ob protein/Leptin (167aa, ~16kD) that controls body weight homeostasis. Exogenous administration of recombinant Ob protein can reduce food intake and body weight. However, Ob protein had no effect in db/db mice suggesting a defect in leptin signaling mechanism. Leptin exert its effects by interacting with leptin receptors (obese receptors). The Ob-R has been shown to be a product of db gene that has long been thought to encode the receptor for a weight-controlling hormone. The Ob-R has at least 6 alternatively spliced forms with modifications at the amino and C-terminus.
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途径
- JAK/STAT Signaling, AMPK Signaling, Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
抗原 See all Leptin (LEP) ELISA试剂盒
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