beta Catenin ELISA 试剂盒
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Quick Overview for beta Catenin ELISA 试剂盒 (ABIN5068366)
抗原
See all beta Catenin (CATNB) ELISA试剂盒适用
检测方法
实验类型
应用范围
样品类型
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交叉反应 （详细）
- Calculated cross reactivity: Hu
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产品特性
- Catenin, beta, Human, ELISA Kit
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组件
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- 1. Microtiter Plate, Catenin antibody-coated microtiter, 1x96 wells.
- 2. Beta-Catenin Detection Ab, 1x11ml
- 3. IgG (HRP) Ab, 1x11ml
- 4. TMB Substrate, 1x 11ml
- 5. STOP Solution, 1x11ml
- 6. Wash Buffer (20X), 1x25ml
- 7. Sample Diluent, 1x25ml.
- 8. Cell Lysis Buffer, 1x15ml
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Catenin, beta (CATNB) ELISA Kit
CATNB 适用: 大鼠 Colorimetric Sandwich ELISA 0.156 ng/mL - 10 ng/mL Plasma, Serum, Tissue Homogenate
Catenin, beta (CATNB) ELISA KitCATNB 适用: 人 Colorimetric Sandwich ELISA 312-20000 pg/mL Cell Culture Supernatant, Plasma, Serum, Tissue Homogenate
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限制
- 仅限研究用
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储存条件
- -20 °C
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储存方法
- -20°C
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- beta Catenin (CATNB) (Catenin, beta (CATNB))
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别名
- Catenin, beta
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背景
- A key downstream effector in the Wnt signaling pathway is b-catenin (1). It is implicated in two major biological processes of vertebrates: early embryonic development (2) and tumorigenesis (3). Casein kinase 1 phosphorylates b-catenin on Ser45. This phosphorylation event primes b-catenin for subsequent phosphorylation by GSK-3 (4-6). GSK-3b destabilizes b-catenin by phosphorylating it at Ser33, 37 and Thr41 (7). Mutations in these phosphorylation sites which result in the stabilization of b-catenin protein levels have been found in many tumor cell lines (8).
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途径
- Peptide Hormone Metabolism
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