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tau ELISA 试剂盒

This 人 tau ELISA Kit is a Colorimetric ELISA Kit designed to quantify 人 tau.
产品编号 ABIN5067912
发货至: 中国

Quick Overview for tau ELISA 试剂盒 (ABIN5067912)

抗原

See all tau ELISA试剂盒
tau (tau Protein)

适用

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检测方法

Colorimetric

应用范围

ELISA

样品类型

Biological Buffers, Cell Culture Supernatant, Cerebrospinal Fluid
  • 原理

    Tau, Total, Human (Tau Protein, Microtubule-associated Protein, MAP) ELISA Kit is used for the quantitative determination of human total Tau protein.

    Analytical Method

    Quantitative

    灵敏度

    > 12 pg/mL

    产品特性

    Tau, Total, Human (Tau Protein, Microtubule-associated Protein, MAP) ELISA Kit

    组件

    • Microtiter Plate 1x96 wells Coated with human Tau antibody
    • Standard 2x1 vial
    • Standard Diluent Buffer. 1x25ml
    • Detection Antibody 1x11ml
    • Pab (HRP), 100X 1x125ul
    • HRP Diluent 1x25ml
    • Wash Buffer, 25X 1x100ml
    • TMB 1x25ml
    • Stop Solution 1x25ml
  • 限制

    仅限研究用
  • 储存条件

    4 °C

    储存方法

    4°C
  • 抗原 See all tau ELISA试剂盒

    tau (tau Protein)

    别名

    Tau

    背景

    Tau is a microtubule associated protein found predominantly in neuronal axons of vertebrate brain. Tau protein is highly soluble and normally attached to axonal microtubules. Tau stabilizes the microtubules and makes them rigid. Tau interacts with actin in the cytoskeleton and neuronal outgrowth, anchors enzymes such as protein kinases and phosphatases, and regulates intracellular vesicle transport. Tau phosphorylation regulates both normal and pathological functions of this protein. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHFs), the building block of neurofibrillary lesions in Alzheimer's disease (AD). Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to neuronal degeneration. Deposition of filamentous tau is implicated in other neurodegenerative diseases including cortical basal degeneration (CBD), progressive supranuclear palsy (PSP), Pick's disease and certain forms of Parkinson's disease.
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