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Thymic Stromal Lymphopoietin ELISA 试剂盒

TSLP 适用: 小鼠 Colorimetric Sandwich ELISA 0.02-1.0 ng/mL Cell Culture Supernatant, Plasma (EDTA), Plasma (citrate), Plasma (heparin), Serum
产品编号 ABIN4987142
发货至: 中国
  • 抗原 See all Thymic Stromal Lymphopoietin (TSLP) ELISA试剂盒
    Thymic Stromal Lymphopoietin (TSLP)
    适用
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    小鼠
    检测方法
    Colorimetric
    实验类型
    Sandwich ELISA
    检测范围
    0.02-1.0 ng/mL
    最低检测浓度
    0.02 ng/mL
    应用范围
    ELISA
    样品类型
    Cell Culture Supernatant, Serum, Plasma (heparin), Plasma (citrate), Plasma (EDTA)
    Analytical Method
    Quantitative
    特异性
    Natural and recombinant Mouse TSLP Ligand
    灵敏度
    7 pg/mL
    试剂未包括
    • Microplate reader.
    • Pipettes and pipette tips.
    • EP tube Deionized or distilled water.
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  • 应用备注
    Detection Wavelength: 450 nm
    样本量
    20 μL
    实验时间
    3 h
    板类型
    Pre-coated
    限制
    仅限研究用
  • 储存条件
    4 °C
  • 抗原 See all Thymic Stromal Lymphopoietin (TSLP) ELISA试剂盒
    Thymic Stromal Lymphopoietin (TSLP)
    别名
    TSLP (TSLP 产品)
    别名
    TSLP ELISA Kit, thymic stromal lymphopoietin ELISA Kit, TSLP ELISA Kit, Tslp ELISA Kit
    背景
    Thymic Stromal Lymphopoietin (TSLP) is a member of the B cell-stimulating factor family. Originally identified from the conditioned medium of a mouse thymic stromal cell line that promoted B-cell development, TSLP is expressed in thymus, spleen, kidney, lung, and bone marrow. Mouse TSLP cDNA encodes a 140 amino acid (aa) residue precursor protein with a 19 aa signal sequence. TSLP activity overlaps with that of IL-7, playing a key role in the development of B cells, as well as stimulating the growth of thymocytes and T cells. TSLP stimulates monocytes to produce T cell-attracting chemokines such as TARC (CCL17) and MDC (CCL22). TSLP also activates dendritic cell-primed CD4 T cells to produce Th2 cytokines, including IL-4, IL-5, IL-13, and TNFα. This hematopoietic cytokine binds to a heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Binding induces activation of STAT3 and STAT5 via phosphorylation. Mouse TSLP shares approximately 43 % amino acid sequence identity with human TSLP.
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