GDF15 ELISA 试剂盒
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- 抗原 See all GDF15 ELISA试剂盒
- GDF15 (Growth Differentiation Factor 15 (GDF15))
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适用
- 人
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 检测范围
- 15.625-1000 pg/mL
- 最低检测浓度
- 15.625 pg/mL
- 应用范围
- ELISA
- 样品类型
- Cell Culture Supernatant, Serum, Plasma (heparin), Plasma (citrate), Plasma (EDTA)
- Analytical Method
- Quantitative
- 特异性
- Natural and recombinant Human GDF-15 Ligand
- 灵敏度
- 7 pg/mL
- 试剂未包括
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- Microplate reader.
- Pipettes and pipette tips.
- EP tube Deionized or distilled water.
- Top Product
- Discover our top product GDF15 ELISA Kit
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Growth Differentiation Factor 15 (GDF15) ELISA Kit
GDF15 适用: 人 Colorimetric Sandwich ELISA 7.8 pg/mL - 500 pg/mL Plasma, Serum, Tissue Homogenate, Urine
Growth Differentiation Factor 15 (GDF15) ELISA KitGDF15 适用: 人 Colorimetric Sandwich ELISA 15.6 pg/mL - 1000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Growth Differentiation Factor 15 (GDF15) ELISA KitGDF15 适用: 大鼠 Colorimetric Competition ELISA 1.56 pg/mL - 100 pg/mL Plasma, Serum, Tissue Homogenate
Growth Differentiation Factor 15 (GDF15) ELISA KitGDF15 适用: 小鼠 Colorimetric Sandwich ELISA 15.6 pg/mL - 1000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Growth Differentiation Factor 15 (GDF15) ELISA KitGDF15 适用: 大鼠 Colorimetric Sandwich ELISA 15.6 pg/mL - 1000 pg/mL Plasma, Serum, Tissue Homogenate
Growth Differentiation Factor 15 (GDF15) ELISA KitGDF15 适用: 人 Colorimetric Sandwich ELISA 2-800 pg/mL Cell Culture Supernatant, Plasma, Serum
Growth Differentiation Factor 15 (GDF15) ELISA KitGDF15 适用: 人 Colorimetric Sandwich ELISA 7.8-500 pg/mL Plasma, Serum, Tissue Homogenate, Urine
Growth Differentiation Factor 15 (GDF15) ELISA KitGDF15 适用: 小鼠 AA 189-303 Colorimetric Sandwich ELISA 15.6-1000 pg/mL Cell Culture Supernatant, Plasma (EDTA), Plasma (heparin), Serum
Growth Differentiation Factor 15 (GDF15) ELISA KitGDF15 适用: 人 AA 197-308 Colorimetric Sandwich ELISA 31.2-2000 pg/mL Cell Culture Supernatant, Plasma (EDTA), Plasma (heparin), Serum
Growth Differentiation Factor 15 (GDF15) ELISA KitGDF15 适用: 大鼠 AA 189-303 Colorimetric Sandwich ELISA
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- 应用备注
- Detection Wavelength: 450 nm
- 样本量
- 20 μL
- 实验时间
- 3 h
- 板类型
- Pre-coated
- 限制
- 仅限研究用
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- 储存条件
- 4 °C
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- 抗原 See all GDF15 ELISA试剂盒
- GDF15 (Growth Differentiation Factor 15 (GDF15))
- 别名
- GDF-15 (GDF15 产品)
- 背景
- Growth and differentiation factor-15 (GDF-15), also known as macrophage inhibitory cytokine-1(MIC-1), placental transforming growth factor-β, prostate-derived factor, and placental bone morphogenetic protein, is a divergent member of the transforming growth factor beta (TGF-β) superfamily (1 - 3). GDF-15 is initially synthesized as a 40 kDa inactive precursor protein. It is then proteolytically cleaved to release the active C-terminal fragment, which is assembled into a disulfide-linked homodimer of 28 kDa to become biologically active GDF-15 (1, 4). In humans, GDF-15 is predominantly expressed in the placenta, with low levels in the kidney, pancreas, and prostate. However, its expression can be rapidly induced by cytokines such as interleukin-1 and TGF-β (1 - 3).GDF-15 has diverse biological functions. Early studies have shown that low serum GDF-15 levels correlate with miscarriages, indicating that it might be able to suppress inflammation in early pregnancy (5, 6). GDF-15 also plays an important role in tumorigenesis and metastasis. It has been observed that in many types of cancers, such as colorectal, breast, and prostate, the expression of GDF-15 is dramatically increased (7 - 9). Additionally, in cancer patients, serum levels of GDF-15 are elevated, which are of value in disease diagnosis and stratification (10 -12). GDF-15 is strongly induced by the tumor suppressor gene p53 and other anti-tumorigenic agents, such as the non-steroidal anti-inflammatory drugs and peroxisome proliferators-activated receptor γ. These findings suggest that GDF-15 may be a downstream target of those signaling pathways that regulate cell cycle arrest and apoptosis (13 - 15). Through the modulation of neuronal pathways important in the regulation of appetite and energy homeostasis, GDF-15 mediates cancer-induced anorexia and weight loss (16).
- 途径
- SARS-CoV-2 Protein Interactome
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