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SensoLyte® 520 小鼠 Renin Assay Kit

FRET 适用: 小鼠 Fluorometric
产品编号 ABIN1882547
发货至: 中国
  • 抗原 See all Renin (REN) 试剂盒
    Renin (REN)
    适用
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    小鼠
    检测方法
    Fluorometric
    应用范围
    Fluorescence Resonance Energy Transfer Microscopy (FRET)
    品牌
    SensoLyte®
    产品特性
    The SensoLyte® 520 Mouse Renin Assay Kit provides a convenient assay for high throughput screening of renin inhibitors and for continuous assay of mouse renin activity using a 5-FAM/QXL™520 FRET peptide. In the FRET peptide the fluorescence of 5-FAM is quenched by QXL™520. Upon cleavage into two separate fragments by renin, the fluorescence of 5-FAM is recovered, and can be monitored at excitation/emission = 490/520 nm.
    Top Product
    Discover our top product REN ELISA Kit
  • 说明

    FRET-based Assay Kit

    限制
    仅限研究用
  • 储存条件
    -80 °C
    储存方法
    Store all kit components at -20 °C, except for Component C. Store Component C at -80 °C. Protect Components A, B, F, and G from light and moisture. Component D can be stored at room temperature for convenience.
  • Takada, Kinugawa, Hirabayashi, Suga, Yokota, Takahashi, Fukushima, Homma, Ono, Sobirin, Masaki, Mizushima, Kadoguchi, Okita, Tsutsui: "Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 114, Issue 7, pp. 844-57, (2013) (PubMed).

    Kakoki, Pochynyuk, Hathaway, Tomita, Hagaman, Kim, Zaika, Mamenko, Kayashima, Matsuki, Hiller, Li, Xu, Grant, Bertorello, Smithies: "Primary aldosteronism and impaired natriuresis in mice underexpressing TGF?1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 14, pp. 5600-5, (2013) (PubMed).

    Kong, Zhu, Shi, Liu, Chen, Bhan, Zhao, Thadhani, Li: "VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system." in: Molecular endocrinology (Baltimore, Md.), Vol. 27, Issue 12, pp. 2116-25, (2013) (PubMed).

    Prysyazhna, Rudyk, Eaton: "Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension." in: Nature medicine, Vol. 18, Issue 2, pp. 286-90, (2012) (PubMed).

    Wang, Deb, Zhang, Sun, Liu, Yoon, Kong, Chen, Chang, Li: "Vitamin D receptor signaling in podocytes protects against diabetic nephropathy." in: Journal of the American Society of Nephrology : JASN, Vol. 23, Issue 12, pp. 1977-86, (2012) (PubMed).

  • 抗原
    Renin (REN)
    别名
    Renin (REN 产品)
    别名
    HNFJ2 Kit, RATRENAA Kit, RENAA Kit, Ren1 Kit, D19352 Kit, Ren Kit, Ren-1 Kit, Ren-A Kit, Ren1c Kit, Ren1d Kit, Rn-1 Kit, Rnr Kit, renin Kit, renin 1 structural Kit, REN Kit, Ren Kit, Ren1 Kit, ren Kit
    背景
    Renin, a highly specific aspartyl protease, cleaves angiotensinogen, to yield angiotensin I. Angiotensin I is further converted into angiotensin II by ACE (Angiotensin Converting Enzyme). Angiotensin II constricts blood vessels leading to increased blood pressure. Discovery of new renin inhibitors for treatment of hypertension is a promising area of research.
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