SSB IgG ELISA 试剂盒
人 SSB IgG ELISA Kit, Colorimetric is an assay for quantification of 人 SSB IgG, that has been mentioned in 1 publication.
(1 reference)
产品编号 ABIN1326889
发货至:
中国
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Quick Overview for SSB IgG ELISA 试剂盒 (ABIN1326889)
抗原
SSB IgG
适用
人
检测方法
Colorimetric
实验类型
Competition ELISA
应用范围
ELISA
样品类型
Serum
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原理
- Diluted patient serum is added to wells coated with purified antigen. IgG specific antibody, if present, binds to the antigen. All unbound materials are washed away and the enzyme conjugate is added to bind to the antibody-antigen complex, if present. Excess enzyme conjugate is washed off and substrate is added. The plate is incubated to allow the hydrolysis of the substrate by the enzyme. The intensity of the color generated is proportional to the amount of IgG specific antibody in the sample.
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Analytical Method
- Qualitative
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板类型
- Pre-coated
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限制
- 仅限研究用
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储存条件
- 4 °C
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: "Association of TLR4 (D299G, T399I), TLR9 -1486T>C, TIRAP S180L and TNF-? promoter (-1031, -863, -857) polymorphisms with risk for systemic lupus erythematosus among South Indians." in: Lupus, Vol. 24, Issue 1, pp. 50-7, (2014) (PubMed).
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- SSB IgG
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物质类
- Antibody
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背景
- Systemic autoimmune disease is characterized by the presence of circulating auto-antibodies directed to a wide variety of cellular antigens.Systemic lupus erythematosis (SLE), commonly referred to as Lupus is the best known of these diseases. Other possible connective tissue diseases include mixed connective tissue disease (MCTD), Sjogren syndrome, sclerodema, and polymyositisdermatomyositis.The majority can be diagnosed by clinical presentation and their antibody profiles to the various antigens involved, which include dsDNA, SM, RNP, SSA, SSB Scl-70, Jo1 and Histones. Therefore, immunoassays for autoantibodies are useful for diagnostic and prognostic evaluations of autoimmune disease. The 48 kd phosphoprotein known as SSB (La) is a transcription termination factor for RNA polymerase III. SSB shuttles between nucleus and cytoplasm and exists both free and as a component of the SSASSB ribonucleoprotein cytoplasmic particle. Autoantibodies to SSB are detected by ELISA in ~70-90% of primary and ~50% of secondary Sj_gren syndrome as well as in ~25% of SLE and ~80% of subacute cutaneous lupus and in the majority of infants with complete heart block. SSB autoantibodies are found only in sera determined to contain SSA autoantibodies by a sensitive method this probably reflects the association of the SS-A and SS-B antigens in a macromolecular complex.
抗原
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