SSA IgG ELISA 试剂盒
The 人 SSA IgG ELISA Kit (ABIN1326888) is a Colorimetric ELISA Kit designed to quantify 人 SSA IgG. This ELISA Kit has been cited in 1 publication.
(1 reference)
产品编号 ABIN1326888
发货至:
中国
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Quick Overview for SSA IgG ELISA 试剂盒 (ABIN1326888)
抗原
SSA IgG
适用
人
检测方法
Colorimetric
实验类型
Competition ELISA
应用范围
ELISA
样品类型
Serum
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原理
- Diluted patient serum is added to wells coated with purified antigen. IgG specific antibody, if present, binds to the antigen. All unbound materials are washed away and the enzyme conjugate is added to bind to the antibody-antigen complex, if present. Excess enzyme conjugate is washed off and substrate is added. The plate is incubated to allow the hydrolysis of the substrate by the enzyme. The intensity of the color generated is proportional to the amount of IgG specific antibody in the sample.
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Analytical Method
- Qualitative
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板类型
- Pre-coated
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限制
- 仅限研究用
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储存条件
- 4 °C
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: "Association of TLR4 (D299G, T399I), TLR9 -1486T>C, TIRAP S180L and TNF-? promoter (-1031, -863, -857) polymorphisms with risk for systemic lupus erythematosus among South Indians." in: Lupus, Vol. 24, Issue 1, pp. 50-7, (2014) (PubMed).
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: "Association of TLR4 (D299G, T399I), TLR9 -1486T>C, TIRAP S180L and TNF-? promoter (-1031, -863, -857) polymorphisms with risk for systemic lupus erythematosus among South Indians." in: Lupus, Vol. 24, Issue 1, pp. 50-7, (2014) (PubMed).
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- SSA IgG
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物质类
- Antibody
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背景
- Systemic autoimmune disease is characterized by the presence of circulating auto-antibodies directed to a wide variety of cellular antigens.Systemic lupus erythematosis (SLE), commonly referred to as Lupus is the best known of these diseases. Other possible connective tissue diseases include mixed connective tissue disease (MCTD), Sjogren syndrome, sclerodema, and polymyositisdermatomyositis.The majority can be diagnosed by clinical presentation and their antibody profiles to the various antigens involved, which include dsDNA, SM, RNP, SSA, SSB, Scl-70, Jo1 and Histones. Therefore, immunoassays for autoantibodies are useful for diagnostic and prognostic evaluations of autoimmune disease. SSA (Ro) antigen (60kd) and 52 kd polypeptides complexed with Ro RNAs are detected in about 75% of primary and secondary Sj_gren syndrome,In 90% of subacute cutaneous lupus and in the vasculitis-associated Sj_gren syndrome, SS-A autoantibodies are present and are accompanied in ~50% by SS-BLa autoantibodies. The coexistence of SSA and SSB autoantibodies probably reflects the presence of these polypeptides on the same particle and the spreading among autoimmunity to these self antigens.
抗原
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