SNCA ELISA 试剂盒
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Quick Overview for SNCA ELISA 试剂盒 (ABIN1059104)
抗原
See all SNCA ELISA试剂盒适用
检测方法
实验类型
应用范围
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Analytical Method
- Quantitative
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产品特性
- This ELISA assay kit provides a standard peptide solution with known concentration to calibrate absorbance readings to concentration.
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组件
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Store all materials at 4 °C:
- Standard peptide: 0.5 mL
- Standard diluent: 1.5 mL
- Microelisa Strip plate: 12 well x 8 strips
- 6 mL HRP-Conjugate Antibody
- 30 x wash solution with 25 mL
- 5 mL Sample diluent
- 5 mL Chromogen Solution A
- 5 mL Chromogen Solution B
- 5 mL Stop Solution
- Instruction Manual
- 2 Closure plate membrane
- Sealed bag
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试剂未包括
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- 37 °C incubator
- Standard absorbance microplate reader
- Precision pipettes and disposable pipette tips
- De-ionized water
- Disposable tubes for sample dilution
- Absorbent paper
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Synuclein, alpha (SNCA) ELISA KitSNCA 适用: 大鼠 Colorimetric Sandwich ELISA 15.625 pg/mL - 1000 pg/mL Plasma, Serum, Tissue Homogenate
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Synuclein, alpha (SNCA) ELISA KitSNCA 适用: 小鼠 Colorimetric Sandwich ELISA 15.625 pg/mL - 1000 pg/mL Plasma, Serum, Tissue Homogenate
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板类型
- Pre-coated
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限制
- 仅限研究用
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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: "38" in: , Vol. 1363, Issue Nucleic acids research, pp. 28-39, (1991)
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- SNCA (Synuclein, alpha (SNCA))
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别名
- alpha-Synuclein
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背景
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Alpha-synuclein (SNCA gene) is a 140 amino acid predominantly cytosolic protein expressed in brain associated with fibrillar structures in Lewy Bodies. Although primary located in the cytosol, alpha-synuclein binds to phospholipid and may assemble into pore-like structures in cellular membranes. Generation of aggregates in Lewy Bodies and/or association of alpha-synuclein with membraneous structures have been attributed to the etiology of Parkinson's Disease. Many additional cellular mechanisms associated with abnormal accumulations of alpha-synuclein in brain have also been proposed as underlying etiologies of the disease.
Parkinson's disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features of the disease include the characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies in brain and spinal cord. -
途径
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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