(Potassium Channel, Subfamily K, Member 3 (KCNK3))
This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008].
Donner, Schullenberg, Geduldig, Hüning, Mersmann, Zacharowski, Kovacevic, Decking, Aller, Schmidt: "Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability." in: Basic research in cardiology, Vol. 106, Issue 1, pp. 75-87, (2010) (PubMed).
Nogueira, Gerry, Mantero, Mariniello, Rainey: "The role of TASK1 in aldosterone production and its expression in normal adrenal and aldosterone-producing adenomas." in: Clinical endocrinology, Vol. 73, Issue 1, pp. 22-9, (2010) (PubMed).
Aliases for KCNK3 抗体
potassium channel, subfamily K, member 3a (kcnk3a) 抗体 potassium two pore domain channel subfamily K member 3 (KCNK3) 抗体 potassium channel, subfamily K, member 3 (Kcnk3) 抗体 potassium two pore domain channel subfamily K member 3 (Kcnk3) 抗体 cTBAK-1 抗体 K2p3.1 抗体 KCNK3 抗体 OAT1 抗体 PPH4 抗体 rTASK 抗体 si:dkey-164m15.1 抗体 TASK 抗体 TASK-1 抗体 Task-1 抗体 TBAK1 抗体