(Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1))
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Schönherr, Gessner, Löber, Heinemann: "Functional distinction of human EAG1 and EAG2 potassium channels." in: FEBS letters, Vol. 514, Issue 2-3, pp. 204-8, (2002) (PubMed).
Schönherr, Löber, Heinemann: "Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin." in: The EMBO journal, Vol. 19, Issue 13, pp. 3263-71, (2000) (PubMed).
Pardo, del Camino, Sánchez, Alves, Brüggemann, Beckh, Stühmer: "Oncogenic potential of EAG K(+) channels." in: The EMBO journal, Vol. 18, Issue 20, pp. 5540-7, (1999) (PubMed).
Occhiodoro, Bernheim, Liu, Bijlenga, Sinnreich, Bader, Fischer-Lougheed: "Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion." in: FEBS letters, Vol. 434, Issue 1-2, pp. 177-82, (1998) (PubMed).
Aliases for KCNH1 抗体
potassium voltage-gated channel subfamily H member 1 (KCNH1) 抗体 potassium channel, voltage gated eag related subfamily H, member 1 (KCNH1) 抗体 potassium voltage-gated channel subfamily H member 1 (LOC490277) 抗体 potassium voltage-gated channel, subfamily H (eag-related), member 1 (Kcnh1) 抗体 potassium voltage-gated channel subfamily H member 1 (Kcnh1) 抗体 potassium voltage-gated channel, subfamily H (eag-related), member 1a (kcnh1a) 抗体 bEAG 抗体 EAG 抗体 EAG1 抗体 Eag1 抗体 h-eag 抗体 kcnh1 抗体 Kv10.1 抗体 M-eag 抗体