KCNA1 抗体
(Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008].
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Latest Publications for our KCNA1 抗体
: "N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity." in: Molecular brain, Vol. 8, pp. 4, (2015) (PubMed).: "Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes." in: Biochimica et biophysica acta, Vol. 1854, Issue 7, pp. 827-33, (2015) (PubMed).
: "The Polarity Protein Pals1 Regulates Radial Sorting of Axons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 29, pp. 10474-84, (2015) (PubMed).
: "Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation." in: Basic research in cardiology, Vol. 110, Issue 5, pp. 505, (2015) (PubMed).
: "Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis." in: Neurobiology of disease, Vol. 73, pp. 96-105, (2014) (PubMed).
: "Neonatal NMDA receptor blockade disrupts spike timing and glutamatergic synapses in fast spiking interneurons in a NMDA receptor hypofunction model of schizophrenia." in: PLoS ONE, Vol. 9, Issue 10, pp. e109303, (2014) (PubMed).
: "Control and plasticity of the presynaptic action potential waveform at small CNS nerve terminals." in: Neuron, Vol. 84, Issue 4, pp. 778-89, (2014) (PubMed).
: "Auditory nerve perinodal dysmyelination in noise-induced hearing loss." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 7, pp. 2684-8, (2014) (PubMed).
: "Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells." in: The European journal of neuroscience, Vol. 39, Issue 11, pp. 1771-83, (2014) (PubMed).
: "Kv7.2 regulates the function of peripheral sensory neurons." in: The Journal of comparative neurology, Vol. 522, Issue 14, pp. 3262-80, (2014) (PubMed).
Aliases for KCNA1 抗体
potassium voltage-gated channel subfamily A member 1 (KCNA1) 抗体potassium voltage-gated channel, shaker-related subfamily, member 1 (KCNA1) 抗体
potassium voltage-gated channel, shaker-related subfamily, member 1 (Kcna1) 抗体
potassium voltage-gated channel subfamily A member 1 (Kcna1) 抗体
fragile site, aphidicolin type, common, fra(12)(q24) (FRA12E) 抗体
AEMK 抗体
AI840627 抗体
EA1 抗体
HBK1 抗体
HUK1 抗体
Kca1-1 抗体
Kcna 抗体
KCNA1 抗体
Kcpvd 抗体
KV1.1 抗体
Kv1.1 抗体
MBK1 抗体
mceph 抗体
Mk-1 抗体
MK1 抗体
RBK1 抗体
Shak 抗体
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