Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Morrison, Jackson-Boeters, Khan, Shimizu, Franklin, Fung, Yoo, Darling: "Identifying Candidate Biomarkers for Pleomorphic Adenoma: A Case-Control Study." in: Head and neck pathology, (2018) (PubMed).
Shinmura, Tao, Yamada, Kataoka, Sanjar, Wang, Yoshimura, Sugimura: "Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity." in: Human mutation, Vol. 24, Issue 3, pp. 273-4, (2004) (PubMed).
Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).
Yousef, Magklara, Diamandis: "KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer." in: Genomics, Vol. 69, Issue 3, pp. 331-41, (2000) (PubMed).