Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008].
Xu, Gupta, Martins, Martins, Fowler, Bush, Finkelstein, Adlard: "Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way." in: Neurobiology of disease, (2015) (PubMed).
Rentero Rebollo, Sabisz, Baeriswyl, Heinis: "Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides." in: Nucleic acids research, Vol. 42, Issue 22, pp. e169, (2014) (PubMed).
Kahn, Hellmark, Leeb-Lundberg, Akbari, Todiras, Olofsson, Wieslander, Christensson, Westman, Bader, Müller-Esterl, Karpman: "Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 12, pp. 7906-15, (2009) (PubMed).