ITM2B 抗体
(Integral Membrane Protein 2B (ITM2B))
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009].
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Latest Publications for our ITM2B 抗体
: "The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases." in: Biochimica et biophysica acta, Vol. 1852, Issue 5, pp. 742-8, (2015) (PubMed).: "Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy. ..." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 88, Issue 7, pp. 694-721, (2008) (PubMed).
Aliases for ITM2B 抗体
integral membrane protein 2B (ITM2B) 抗体integral membrane protein 2B (Itm2b) 抗体
integral membrane protein 2Ba (itm2ba) 抗体
integral membrane protein 2B L homeolog (itm2b.L) 抗体
integral membrane protein 2B (itm2b) 抗体
integral membrane protein 2b (itm2b) 抗体
integral membrane protein 2Bb (itm2bb) 抗体
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