Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism (By similarity).
Tan, Adya, Farhatullah, Lewandowski, OHare, Lehnert, Randeva: "Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose." in: Diabetes, Vol. 57, Issue 4, pp. 801-8, (2008) (PubMed).
Yang, Lee, Hu, Pray, Wu, Hansen, Shuldiner, Fried, McLenithan, Gong: "Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action." in: American journal of physiology. Endocrinology and metabolism, Vol. 290, Issue 6, pp. E1253-61, (2006) (PubMed).
Tsuji, Uehori, Matsumoto, Suzuki, Matsuhisa, Toyoshima, Seya: "Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 23456-63, (2001) (PubMed).