This protein carries no "tag". The protein has a calculated MW of 26 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
状态
Lyophilized
溶解方式
Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
缓冲液
50 mM Tris, 100 mM Glycine, pH 7.5
注意事项
Avoid repeated freeze-thaw cycles.
储存条件
-20 °C
储存方法
Store at -20°C in lyophilized state after receipt. For long term storage, upon reconstitution rhIgG1 Fc should be aliquot and store at -20°C or -80°C.
Buecheler, Winzer, Tonillo, Weber, Gieseler: "Impact of Payload Hydrophobicity on the Stability of Antibody-Drug Conjugates." in: Molecular pharmaceutics, Vol. 15, Issue 7, pp. 2656-2664, (2019) (PubMed).
Tao, Zhang, Meraner, Tovaglieri, Wu, Gerhard, Zhang, Stallcup, Miao, He, Hurdle, Breault, Brass, Dong: "Frizzled proteins are colonic epithelial receptors for C. difficile toxin B." in: Nature, Vol. 538, Issue 7625, pp. 350-355, (2017) (PubMed).
Zhou, Wang, Tong, Okamoto, Shen, Zaro: "Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery." in: Biomaterials, Vol. 117, pp. 24-31, (2017) (PubMed).
West, Pan, Tonsing-Carter, Hernandez, Pierce, Styke, Bowie, Garcia, Kocherginsky, Conzen: "GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome." in: Molecular cancer research : MCR, Vol. 14, Issue 8, pp. 707-19, (2017) (PubMed).
Grenga, Kwilas, Donahue, Farsaci, Hodge: "Inhibition of the angiopoietin/Tie2 axis induces immunogenic modulation, which sensitizes human tumor cells to immune attack." in: Journal for immunotherapy of cancer, Vol. 3, pp. 52, (2015) (PubMed).
Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.