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抗Human IRF1 抗体:
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抗Rat (Rattus) IRF1 抗体:
Human Monoclonal IRF1 Primary Antibody for ELISA, WB - ABIN561520
Baumjohann, Okada, Ansel: Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development. in Journal of immunology (Baltimore, Md. : 1950) 2011
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Following spring viremia of carp (显示 ANKRD1 抗体) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (显示 ANKRD1 抗体) virus. data provide evidence that fish and mammals have evolved a similar IRF (显示 TRIM63 抗体)-dependent regulatory mechanism fine-tuning IFN gene activation.
IRF1 served as tumor suppressor in the regulation of cholangiocarcinoma cells proliferation, cell cycle, migration and invasion
this study shows that IRF-1 is a regulator of lipopolysaccharide -induced endothelial proinflammatory activation
These results revealed that IRF-1 is involved in the IFN-inducible expression of Nmi (显示 MYO1C 抗体).
our results indicated that IL-1beta (显示 IL1B 抗体) treatment resulted in a significant increase in expression of the transcriptional factor interferon regulatory factor-1 (IRF-1) at both the mRNA and protein levels, which was significantly ameliorated by treatment with Nebivolol. The combination of these findings suggests that Nebivolol can potentially be applied in human osteoarthritis treatment
The authors observe that IRF1 expression is mediated by ZEB1 (显示 ZEB1 抗体) de-repression, and the study demonstrates how airway remodelling/fibrosis is associated with a defective mucosal antiviral response through ZEB1 (显示 ZEB1 抗体)-initiated epigenetic silencing in respiratory virus infection.
These unprecedented data suggest that IRF1 and NF-kappaB (显示 NFKB1 抗体) orchestrate the TLR4 (显示 TLR4 抗体)-primed immunomodulatory response of hMSCs and that this response also involves the PI3K (显示 PIK3CA 抗体) pathway.
Zinc is capable of ameliorating the allogeneic immune reaction by enhancement of antigen-specific iTreg cells due to modulation of essential molecular targets by upregulation of Foxp3 (显示 FOXP3 抗体) and KLF-10 (显示 KLF10 抗体) and downregulation of IRF-1.
As a measure of PD-L1 (显示 CD274 抗体) expression capability, IRF-1 expression may be a more valuable predictive biomarker for anti-PD-1 (显示 PDCD1 抗体) therapy than PD-L1 (显示 CD274 抗体) itself.
Upregulation of IRF1 in human adipocytes leads to phenotypes associated with obesity-related inflammation.
Regulation of transcriptional activators by DNA-binding domain (DBD) ubiquitination has shown that, when attached to the DBD of either p53 or IRF-1, ubiquitin is orientated towards, and makes contact with, the DNA.
Given these results, porcine IRF1 plays potential roles in cellular antiviral responses against swine viruses.
In a healthy swine model, elevated levels of endothelial IRF-1 were also observed within atherosusceptible regions of the aorta by Western blot analysis and immunohistochemistry, implicating arterial hemodynamics in the regulation of IRF-1 expression.
The results suggested that the porcine IRF1 gene is strong candidate gene for these immune traits in pig.
IRF-1 may be a critical factor in augmenting LPS (显示 TLR4 抗体)-induced oxidative stress and mitochondrial damage in macrophages.
IRF-1 plays a key role in controlling caspase-1 (显示 CASP1 抗体)-dependent pyroptosis and inflammation.
Results indicate IRF-1 is one of the key transcriptional factors for the prevention of neointimal formation involving angiotensin II type 2 receptors.
Data show that HCFC2 (显示 HCFC2 抗体) is a critical component of the IRF1 and IRF2 (显示 IRF2 抗体) transcriptional machinery that regulates Tlr3 (显示 TLR3 抗体) gene expression.
Data show that the Japanese encephalitis virus (JEV)-induced expression of miR (显示 MLXIP 抗体)-301a led to inhibition of the production of the transcription factor IFN regulatory factor 1 (IRF1) and the signaling protein suppressor of cytokine signaling 5 (SOCS5 (显示 SOCS5 抗体)).
Our studies uncovered the critical role of two transcription factors, IRF1 and BATF, in preparing the chromatin landscape for induction of the Tr1 (显示 TXNRD1 抗体) gene network in response to IL-27 (显示 IL27 抗体) signaling, where BATF acted as a pioneer factor and prepared the genomic landscape for the binding of additional transcription factors that define the Tr1 (显示 TXNRD1 抗体) lineage.
IRF-1 and interferon-alpha (显示 IFNA 抗体) with interferon-beta (显示 IFNB1 抗体) cooperate to control acute gammaherpesvirus infection.
this study shows that binding motifs for the transcription factors STAT1 (显示 STAT1 抗体) and IRF1 are associated with robust and IL-4 (显示 IL4 抗体)-resistant responses to IFN-gamma (显示 IFNG 抗体) in macrophages
5AZ had a protective effect after MI by potentiation of IRF1 sumoylation and is suggested as a novel therapeutic intervention for cardiac repair.
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.
interferon regulatory factor 1
, interferon regulatory factor 11
, interferon responsive factor 1