Swinholide A
Quick Overview for Swinholide A (ABIN924961)
应用范围
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原理
- Swinholide A is a natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells.
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纯度
- > 98 % (HPLC)
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Anacardic AcidInh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
ResveratrolAct 501-36-0 3,4',5-Trihydroxy-trans-stilbene
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
AS-8351Inh 796-42-9 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
UNC-0379Inh 1620401-82-2 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
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应用备注
- Can be used in cell biology to distinguish between the effects induced by increasing intracellular concentrations of G-actin from those induced by a reduction in F-actin.
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说明
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Formula: C78H132O20
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限制
- 仅限研究用
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状态
- Oil
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储存条件
- -20 °C
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背景
- Swinholide A is a 44-carbon dimeric dilactone ring macrolide isolated from the marine sponge Theonella swinhoei. In vitro, it sequesters actin dimers with a binding stochiometry of 1:1, and it rapidly severs F-actin with high cooperativity. Swinholice A is potently cytotoxic by disruption of the actin cytoskeleton. It does not block progression of cells through the cell cycle, but does prevent cytokinesis. Cytotoxcity: Cell Type IC50 (µg/ml) KB Oral, epidermoid cell carcinoma 0.04 HT-1080 Fibrosarcoma 0.017 PC-3 Lung, adenocarcinoma 6.0 PC-9 Lung, adenocarcinoma 0.13 PC-10 Lung, squamous cell carcinoma 0.11 PC-13 Lung, large cell carcinoma 0.10 Daudi Burkitt lymphoma 0.036.
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分子量
- 1388.9 Da
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