GW-2580
Our Local Distributor
北京 101111
Quick Overview for GW-2580 (ABIN7885815)
Chemical Name
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宿主
- 合成
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原理
- An Inhibitor of Trk Receptors and cFMS/CSF-1 Receptor Kinases
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特异性
- Toxin target: CSF-1R receptor, Trk receptor
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产品特性
- GW-2580 is a potent and selective inhibitor of cFMS/CSF-1 receptor kinase, shown to completely and selectively inhibit human cFMS kinase activity at 60 nM, and fully suppress CSF-1 induced cell growth at 1 μM, in vitro. Orally bioavailable and active in vivo1. GW 2580 also binds to TrkB, TrkC and TrkA with Kd values of 36 nM, 120 nM and 630 nM, respectively,2 and fully inhibits BDNF-induced TrkB phosphorylation in cells at 3 μM3.
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纯度
- >99 %
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Formula
- C20H22N4O3.
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Solubility
- Soluble up to 100mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
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Thapsigargin
67526-95-8 (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6 ,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[ [(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutox y)azuleno[4,5-b]furan-7-yl octanoate.
K252a97161-97-2 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-.
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
GeldanamycinInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
(±)-Bay K864471145-03-4 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl) phenyl]-3-pyridinecarboxylic acid, methyl ester.
Capsaicin404-86-4 (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide.
Chelerythrine chloride3895-92-9 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride.
K252b99570-78-2 (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid.
GS9671262618-39-2 (6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine)
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限制
- 仅限研究用
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状态
- Powder
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注意事项
- Centrifuge all product preparations before use (10000 x g 5 min).
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储存条件
- -20 °C
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储存方法
- Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
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分子量
- 366.41
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CAS-编号
- 870483-87-7
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