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(±)-Bay K8644

Name: (±)-Bay K8644
SKU: ABIN7885716
Availability: OutOfStock

71145-03-4 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl) phenyl]-3-pyridinecarboxylic acid, methyl ester.

Molecular structure of ABIN7885716. ((±)-Bay K8644)

Left: I-V relation before (squares) and during (circles) bath perfusion of 5 μM (±)-Bay K8644 (ABIN7885716). ((±)-Bay K8644)

BCA

Cells were preincubated with or without EGTA or Nifedipine for 20 min then stimulated with (±)-Bay K8644 (ABIN7885716) or with Ionomycin for 10 min. ((±)-Bay K8644)

BCA

3 images

产品编号 ABIN7885716

发货至: 中国

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Quick Overview for (±)-Bay K8644 (ABIN7885716)

Chemical Name

1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl) phenyl]-3-pyridinecarboxylic acid, methyl ester.

宿主

合成

原理

An L-Type Voltage-Gated Ca2+ Channel Activator

特异性

Toxin target: L-type Ca2+ channels

产品特性

(±)-Bay K8644 is a dihydropyridine that acts as an L-type, voltage-gated Ca2+ channel agonist. The (-)-enantiomer has strong Ca2+ channel agonist properties, whereas the (+)-enantiomer has weak Ca2+ channel antagonist activity. The net activity of the racemic mix is L-type channel opening. In the presence of this agonist, channels tend to open for longer periods causing a large increase in the channel microscopic response1-4. (±)-Bay K8644 is also an inhibitor (by increasing the inactivation) of a Shaker KV channel5.

纯度

>99 % (HPLC)

Formula

C16H15F3N2O4.

Solubility

Ethanol, methanol or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Thapsigargin
67526-95-8 (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6 ,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[ [(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutox y)azuleno[4,5-b]furan-7-yl octanoate.

K252a
97161-97-2 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-.

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Capsaicin
404-86-4 (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide.

Chelerythrine chloride
3895-92-9 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride.

K252b
99570-78-2 (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid.

GS967
1262618-39-2 (6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine)

GW-2580
870483-87-7 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine.

限制

仅限研究用
状态

Powder

注意事项

Centrifuge all product preparations before use (10000 x g 5 min).

储存条件

-20 °C

储存方法

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
分子量

356.3

CAS-编号

71145-03-4