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Tranylcypromine hemisulfate (±)

Inh Cell-permeable 13492-01-8 Trans (±)-2-phenylcyclopropanamine, hemisulfate salt

/ (Tranylcypromine hemisulfate (±))

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产品编号 ABIN7233300

发货至: 中国

Datasheet as PDF

Quick Overview for Tranylcypromine hemisulfate (±) (ABIN7233300)

应用范围

Inhibition (Inh)

Chemical Name

Trans (±)-2-phenylcyclopropanamine, hemisulfate salt

Permeability

Cell-permeable

原理

Demethylase inhibitor

产品特性

Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) IC50 < 2 μM. Tranylcypromine treatment of P19 embryonal carcinoma cells resulted in global increase of H3K4 methylation along with transcriptional derepression of two BHC110 target genes, Egr1 and Oct4. When combined with CHIR99021, induces the generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Reduces proliferation, cell cycle progression and invasiveness of endometriotic stromal cells. Upregulates CD86 expression in THP1 cells. Monoamine oxidase inhibitor. Cell permeable and active in vivo.

纯度

>98 %

Formula

C9H11N 1/2(H2SO4)

Solubility

Soluble in Water (up to 25 mg/ml).
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限制

仅限研究用
状态

Powder

储存条件

-20 °C
背景

2-PCPA, SKF-385,Epigenetics,Protein demethylase,Monoamine oxidase,Stem cells,Neuroscience,Mood disorders,Chromatin,Posttranslational Modification

分子量

182.23

CAS-编号

13492-01-8

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