Splitomicin
Quick Overview for Splitomicin (ABIN7233294)
应用范围
Chemical Name
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原理
- SIRT1 inhibitor
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产品特性
- Initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA. Inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome. Reverses ischemic preconditioning-induced cardioprotection in a mouse model.
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纯度
- >98 %
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Formula
- C13H10O2
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Solubility
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
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限制
- 仅限研究用
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状态
- Powder
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储存条件
- RT
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背景
- Splitomycin,Epigenetics,Protein deacetylase,Ischemia,Heart disease,Posttranslational modification,Chromatin
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分子量
- 198.22
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CAS-编号
- 5690-03-9
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