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SP2509

Inh 1423715-09-6 (E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide

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产品编号 ABIN7233293

发货至: 中国

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中国
北京 101111

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Quick Overview for SP2509 (ABIN7233293)

应用范围

Inhibition (Inh)

Chemical Name

(E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide

原理

LSD1 Inhibitor

产品特性

SP2509 is a potent (IC50 = 13 nM), reversible, non-competitive inhibitor of histone demethylase LSD1 (KDM1A), selective over the closely related flavin enzymes MAO A & B, lactate dehydrogenase, several CYPs, or hERG. It inhibits growth and induces differentiation of cancer stem cells, e.g. AML progenitor cells, and promotes autophagy in neuroblastoma cells. It also causes cancer cell death independent if LSD1, possibly through downregulation of Bcl-2 and Mcl-1. Also inhibits HSV-1 infection by blocking viral DNA replication and gene expression.

纯度

>98 %

Formula

C19H20ClN3O5S

Solubility

Soluble in DMSO (up to at least 25 mg/ml)
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限制

仅限研究用
状态

Powder

储存条件

-20 °C
背景

Bcl,Epigenetics,Posttranslational modification,Protein demethylase,Cell death,Cancer Stem Cells,Infectious disease,Cancer,Autophagy,Chromatin

分子量

437.90

CAS-编号

1423715-09-6