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Santacruzamate A

Inh 1477949-42-0 N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester

1 image

产品编号 ABIN7233286

发货至: 中国

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Quick Overview for Santacruzamate A (ABIN7233286)

应用范围

Inhibition (Inh)

Chemical Name

N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester

原理

Ultrapotent HDAC2 inhibitor

产品特性

A highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively). Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors. Potential therapeutic agent for breast cancer. Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance. Ameliorates Alzheimer's disease-like pathology in mouse models.

纯度

>98 %

Formula

C15H22N2O3

Solubility

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
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限制

仅限研究用
状态

Powder

注意事项

GHS – Classification
Not a hazardous substance

储存条件

-20 °C
背景

Epigenetics,Posttranslational modification,Protein deacetylase,Neuroscience,Cell death,Cellular stress,Cancer,Neurodegeneration,Apoptosis inducer,Chromatin

分子量

278.35

CAS-编号

1477949-42-0