GSK-J1
Quick Overview for GSK-J1 (ABIN7233258)
应用范围
Chemical Name
Permeability
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原理
- JMJ H3K27 Demethylase inhibitor (cell impermeable)
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产品特性
- Potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available.
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纯度
- >98 %
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Formula
- C22H23N5O2
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Solubility
- Soluble in DMSO (up to 20 mg/ml).
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限制
- 仅限研究用
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状态
- Powder
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储存条件
- RT
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背景
- Epigenetics,Protein demethylase,Posttranslational modification,Chromatin
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分子量
- 389.46
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CAS-编号
- 1373422-53-7
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