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GSK3326595

Name: GSK3326595
Brand: antibodies-online
SKU: ABIN7233257
Availability: OutOfStock

Inh 1616392-22-3 6-[(1-Acetylpiperidine-4-yl)amino]-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide

1 image

产品编号 ABIN7233257

发货至: 中国

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中国
北京 101111

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Quick Overview for GSK3326595 (ABIN7233257)

应用范围

Inhibition (Inh)

Chemical Name

6-[(1-Acetylpiperidine-4-yl)amino]-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide

原理

Selective PRMT5 inhibitor

产品特性

GSK3326595 is a potent (IC50 = 6.2nM), selective (>4000-fold over 20 other methyltransferases), SAM uncompetitive, peptide competitive inhibitor of PRMT5. PRMT5 inhibition activated the p53 pathway via induction of alternative splicing of MDM4 leading to a potent anti-proliferative response both in vitro and in vivo. Combination therapy with palbociclib (CDK4/6 inhibitor) and GSK3326595 lead to increased efficacy of palbociclib in treating native and resistant models of melanoma via regulation of the PRMT5-MDM4 axis. Currently in clinical Trials.

纯度

>98 %

Formula

C24H32N6O3

Solubility

Soluble in DMSO (up to 20 mg/ml)
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Radicicol
Inh 12772-57-5

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限制

仅限研究用
状态

Powder

储存条件

-20 °C
背景

EPZ015938,Proliferation,Epigenetics,Posttranslational modification,Protein methyltransferase,RNA,Cancer,Chromatin,p53

分子量

452.56

CAS-编号

1616392-22-3