GSK2879552
Quick Overview for GSK2879552 (ABIN7233256)
应用范围
Chemical Name
-
-
原理
- Lysine Demethylase inhibitor
-
产品特性
- GSK289552 is potent, selective, and irreversible inhibitor of Lysine Demethylase 1 (LSD1) via covalent modification of the LSD1 cofactor FAD (Ki = 1.7 μM). It is selective for LSD1 over the closely related LSD2, MAO-A, MAO-B, and the FAD dependent enzymes D-amino acid oxidase and glutathione reductase. Tested against a panel of 165 cancer cell lines, GSK2879552 inhibited the proliferation of 9 small cell lung carcinoma lines and 20 AML cell lines.
-
纯度
- >98 %
-
Formula
- C23H28N2O2 •2HCl
-
Solubility
- Soluble in DMSO (up to 25 mg/ml) and in Water (up to at least 25 mg/ml)
-
-
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Anacardic AcidInh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
ResveratrolAct 501-36-0 3,4',5-Trihydroxy-trans-stilbene
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
AS-8351Inh 796-42-9 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
UNC-0379Inh 1620401-82-2 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
-
-
限制
- 仅限研究用
-
-
-
状态
- Powder
-
储存条件
- -20 °C
-
-
-
背景
- Epigenetics,Proliferation,Protein demethylase,Cancer,Posttranslational modification,Chromatin
-
分子量
- 437.40
-
CAS-编号
- 1401966-69-5
-
-
