EED-226
Quick Overview for EED-226 (ABIN7233249)
应用范围
Chemical Name
-
-
原理
- PRC2 methyltransferase inhibitor
-
产品特性
- Potent and selective allosteric inhibitor (IC50 = 23.4 nM) of the EED subunit of the methyltransferase polycomb repressive complex 2 (PRC2).1,2 Strongly inhibits proliferation of lymphoma cells with EZH2 mutations and causes shrinkage and slower tumor growth in mice in a subcutaneous xenograft model of Karpas422.
-
纯度
- >98 %
-
Formula
- C17H15N5O3S
-
Solubility
- Soluble in DMSO (up to 25 mg/ml)
-
-
-
-
限制
- 仅限研究用
-
-
-
状态
- Powder
-
储存条件
- -20 °C
-
-
-
背景
- Epigenetics,Proliferation,Protein methyltransferase,Immunology,Cancer,Posttranslational modification,Chromatin
-
分子量
- 369.40
-
CAS-编号
- 2083627-02-3
-
-