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Quick Overview for Decitabine (ABIN7233248)
Chemical Name
Permeability
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原理
- DNA hypomethylation agent
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产品特性
- Inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes suppressing the growth of human tumor cell lines1. Increases stem cell reprogramming efficiency. Stimulates osteogenic differentiation of human bone marrow stromal cells2. Induces differentiation and growth inhibition in IDH1 mutant glioma cells and decreases tumor growth in vivo3. An extremely useful reagent for inhibition of DNA methyltransferases in a variety of experimental systems including zebrafish embryos4. Cell permeable. Active in vivo.
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纯度
- >98 %
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Formula
- C8H12N4O4
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Solubility
- Soluble in DMSO (up to 25 mg/ml) or in Water (up to 11 mg/ml).
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Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
GeldanamycinInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- BiotinInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Herbimycin AInh 70563-58-5 [(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
17-GMB-APA-GAInh [(3R,5S,6R,7S,10S,11S)-21-[3-[4-(2,5-dioxopyrrol-1-yl)butanoylamino]propylamino]-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
TEMPOInh 2564-83-2 2,2,6,6-Tetramethylpiperidine 1-oxyl, 2,2,6,6-Tetramethyl-1-piperidinyloxy, free radical, (2,2,6,6-Tetramethyl-1-piperidinyl)oxidanyl, 1,1,5,5-tetramethylpentamethylene nitroxide, 2,2,6,6-Tetramethylpiperidine-1-oxyl
Triacsin CInh 76896-80-5 (3E)-1-Oxo-3-[(2E,4E,7E)-2,4,7-undecatrien-1-ylidene]triazane
TPCKInh 402-71-1 N-(4-Chloro-3-oxo-1-phenyl-2-butanyl)-4-methylbenzenesulfonamide
StaurosporineInh 62996-74-1 (2S,3R,4R,6R)-3-Methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
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限制
- 仅限研究用
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状态
- Powder
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储存条件
- -20 °C
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储存方法
- -20°C
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背景
- NSC-127716,Epigenetics,DNA methyltransferase,Stem cells,Cancer,DNA damage,Chromatin
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分子量
- 228.2
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CAS-编号
- 2353-33-5
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