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CPI-455

Inh 1628208-23-0 7-Oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile

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产品编号 ABIN7233243

发货至: 中国

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Quick Overview for CPI-455 (ABIN7233243)

应用范围

Inhibition (Inh)

Chemical Name

7-Oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile

原理

Lysine demethylase KDM5 inhibitor

产品特性

CPI-455 (1628208-23-0) is a potent (IC50 = 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C). CPI-455 reduced the number of drug-tolerant persister cancer cells (DTPs) in a dose-dependent, KDM5-dependent manner in multiple cell lines treated with standard chemotherapy or targeted agents. CPI-455 synergized with 5-aza-2'-deoxycytidine (DAC) to reduce the viability of luminal breast cancer cells in vitro. KDM5 demethylases have recently been shown to repress the immune response to tumors via suppression of STING.

纯度

>98 %

Formula

C16H14N4O

Solubility

Soluble in DMSO (up to at least 25 mg/ml)
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限制

仅限研究用
状态

Powder

储存条件

-20 °C
背景

Epigenetics,Chromatin,Protein demethylase,STING,Immunology,Cancer,Posttranslational modification,Cytokine

分子量

278.32

CAS-编号

1628208-23-0