BIX-01294
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- 应用范围
- Inhibition (Inh)
- 原理
- Histone methyl transferase inhibitor
- 产品特性
- BIX-01294 is a selective inhibitor of G9a histone methyltransferase (G9aHMTase, IC50 = 1.7 μM) as well as GLP HMTase (IC50 = 38 μM) leading to a decrease in H3K9me2(histone H3 lysine 9 methylation) in vitro. BIX-01294 facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming. BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells.
- 纯度
- >98 %
- Chemical Name
- 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride
- Formula
- C28H38N6O2
- Solubility
- Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml).
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- 限制
- 仅限研究用
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- 状态
- Powder
- 储存条件
- RT
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- 背景
- Epigenetics,Protein methyltransferase,Neuroscience,Stem cells,Posttranslational modification,Chromatin
- 分子量
- 600.02
- CAS-编号
- 935693-62-2
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