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BIX-01294

Inh 935693-62-2 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride
产品编号 ABIN7233235
发货至: 中国
  • 应用范围
    Inhibition (Inh)
    原理
    Histone methyl transferase inhibitor
    产品特性
    BIX-01294 is a selective inhibitor of G9a histone methyltransferase (G9aHMTase, IC50 = 1.7 μM) as well as GLP HMTase (IC50 = 38 μM) leading to a decrease in H3K9me2(histone H3 lysine 9 methylation) in vitro. BIX-01294 facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming. BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells.
    纯度
    >98 %
    Chemical Name
    2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride
    Formula
    C28H38N6O2
    Solubility
    Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml).
  • 限制
    仅限研究用
  • 状态
    Powder
    储存条件
    RT
  • 背景
    Epigenetics,Protein methyltransferase,Neuroscience,Stem cells,Posttranslational modification,Chromatin
    分子量
    600.02
    CAS-编号
    935693-62-2
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