AS-8351
Quick Overview for AS-8351 (ABIN7233233)
应用范围
Chemical Name
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原理
- KDM5B histone demethylase inhibitor
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产品特性
- AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts1. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.
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纯度
- >98 %
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Formula
- C17H13N3O2
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Solubility
- Soluble in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
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限制
- 仅限研究用
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状态
- Powder
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注意事项
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GHS – Classification
Not a hazardous substance or mixture -
储存条件
- -20 °C
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背景
- NSC-51355,Epigenetics,Protein demethylase,Stem cells,Heart disease,Posttranslational modification,Chromatin
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分子量
- 291.3
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CAS-编号
- 796-42-9
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