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AS-8351

Inh 796-42-9 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone

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产品编号 ABIN7233233

发货至: 中国

Datasheet as PDF

应用范围

Inhibition (Inh)

原理

KDM5B histone demethylase inhibitor

产品特性

AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts1. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.

纯度

>98 %

Chemical Name

2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone

Formula

C17H13N3O2

Solubility

Soluble in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
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限制

仅限研究用
状态

Powder

注意事项

GHS – Classification
Not a hazardous substance or mixture

储存条件

-20 °C
背景

NSC-51355,Epigenetics,Protein demethylase,Stem cells,Heart disease,Posttranslational modification,Chromatin

分子量

291.3

CAS-编号

796-42-9