Apicidin
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北京 101111
Quick Overview for Apicidin (ABIN7233232)
应用范围
Chemical Name
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原理
- HDAC inhibitor
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产品特性
- Apicidin is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's). It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression causing cell cycle arrest in the G1 phase. Apicidin dramatically decreases HIF-1α protein levels and transcriptional activity in human and mouse tumor cell lines.
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纯度
- >98 %
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Formula
- C34H49N5O6
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Solubility
- Soluble in DMSO (up to 1 mg/ml)
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Anacardic AcidInh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
AS-8351Inh 796-42-9 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
UNC-0379Inh 1620401-82-2 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
GSK3326595Inh 1616392-22-3 6-[(1-Acetylpiperidine-4-yl)amino]-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide
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限制
- 仅限研究用
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状态
- Powder
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注意事项
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GHS – Classification
Not a hazardous substance or mixture -
储存条件
- -20 °C
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背景
- Autophagy,Epigenetics,Posttranslational modification,Transcription,Protein deacetylase,Stem cells,Oxidative stress,Cell death,Infectious disease,Cancer,Cell cycle,Chromatin
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分子量
- 623.78
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CAS-编号
- 183506-66-3
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