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北京 101111
Quick Overview for AK-7 (ABIN7233230)
应用范围
Chemical Name
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原理
- SIRT2 inhibitor
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产品特性
- A selective Sirt2 inhibitor (IC50=15.5 956M) which does not inhibit Sirt1 or Sirt31. It down-regulates cholesterol biosynthesis genes in primary striatal neurons. Displays neuroprotective effects in Huntington's disease mouse models including improved motor function, extended survival and reduced brain atrophy all of which were associated with reduced aggregated mutant huntingtin. Ameliorates β-amyloid pathology and cognitive imparement in an Alzheimer's disease mouse model.
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纯度
- >98 %
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Formula
- C19H21BrN2O3S
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Solubility
- Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Anacardic AcidInh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
AS-8351Inh 796-42-9 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
UNC-0379Inh 1620401-82-2 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
GSK3326595Inh 1616392-22-3 6-[(1-Acetylpiperidine-4-yl)amino]-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide
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限制
- 仅限研究用
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状态
- Powder
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储存条件
- RT
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背景
- Epigenetics,Posttranslational modification,Protein deacetylase,Neuroscience,Ageing,Neurodegeneration,Cholesterol metabolism,Chromatin
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分子量
- 437.36
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CAS-编号
- 420831-40-9
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