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5-Azacytidine

Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

/ (5-Azacytidine)

1 image

产品编号 ABIN7233228

发货至: 中国

Datasheet as PDF

Quick Overview for 5-Azacytidine (ABIN7233228)

应用范围

Inhibition (Inh)

Chemical Name

4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Permeability

Cell-permeable

原理

DNA hypomethylation agent

产品特性

Specific inhibitor of DNA methyltransferase. Incorporates into DNA and covalently reacts with and inhibits DNA methyltransferases. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Induces cardiac differentiation of human mesenchymal stem cells by activating ERK. Induces apoptosis in multiple myeloma cells via ATR-mediated DNA double strand breaks. Cell permeable.

纯度

>98 %

Formula

C8H12N4O5

Solubility

Soluble in DMSO (up to 25 mg/ml), or in Water (up to 12 mg/ml).
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限制

仅限研究用
状态

Powder

注意事项

GHS – Classification
Acute toxicity, Oral (Category 4), H302
Germ cell mutagenicity (Category 2), H341
Carcinogenicity (Category 1A), H350
Reproductive toxicity (Category 1B), H360
Specific target organ toxicity - repeated exposure (Category 1), H372
Long-term (chronic) aquatic hazard (Category 1), H410

储存条件

-20 °C
背景

Ladakamycin, U-18496, NSC-102816, AzaC,Epigenetics,Chromatin,DNA methyltransferase,Stem cells,Cell death,Infectious disease,Apoptosis inducer,DNA damage

分子量

244.2

CAS-编号

320-67-2

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