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Geldanamycin- FITC

Name: Geldanamycin- FITC
Brand: antibodies-online
SKU: ABIN1027734
Availability: OutOfStock

Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

1 image

(1 reference)

产品编号 ABIN1027734

发货至: 中国

Quick Overview for Geldanamycin- FITC (ABIN1027734)

应用范围

Inhibition (Inh)

Chemical Name

(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

原理

Hsp90 fluorescent probe

特异性

Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases. It induces the inactivation, destabilization and eventual degradation of HIF-1alpha. This is specifically a novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for Hsp90 inhibitors. May also be used for detection of cell surface Hsp90. Other geldanamycin fluorophores (BODPY) have been reported and used in FP HTS assays.

产品特性

Hsp90 inhibitor.

纯度

>98 % (TLC), NMR (Conforms)

Formula

C55H63N5O13S

Solubility

May be dissolved in DMSO (>10 mg/ml)
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

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说明

Source: Synthetic.
Appearance: Purple Solid

限制

仅限研究用
状态

Solid

注意事项

Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects

注意事项

Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects

储存条件

-20 °C
Austin, Pettit, Magnolo, Sanvoisin, Chen, Wood, Freeman, Pengelly, Hughes: "Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors." in: Journal of biomolecular screening, Vol. 17, Issue 7, pp. 868-76, (2012) (PubMed).
分子量

1034.2

CAS-编号

30562-34-6