我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

Geldanamycin

Name: Geldanamycin
Brand: antibodies-online
SKU: ABIN1027731
Availability: OutOfStock

Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Image no. 1 for Geldanamycin (ABIN1027731) (Geldanamycin)

1 image

(2 references)

产品编号 ABIN1027731

发货至: 中国

Datasheet as PDF

Quick Overview for Geldanamycin (ABIN1027731)

应用范围

Inhibition (Inh)

Chemical Name

(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

原理

Hsp90 inhibitor

特异性

Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases. It induces the inactivation, destabilization and eventual degradation of HIF-1alpha. This is specifically a novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for Hsp90 inhibitors. May also be used for detection of cell surface Hsp90. Other geldanamycin fluorophores (BODPY) have been reported and used in FP HTS assays.

产品特性

Hsp90 inhibitor.

纯化方法

Produced by fermentation

纯度

>95 %

Formula

C29H40N2O9

Solubility

Slightly soluble in methanol, chloroform or DMSO (10 mg/ml); insoluble in water
Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Anacardic Acid
Inh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid

EX-527
Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Resveratrol
Act 501-36-0 3,4',5-Trihydroxy-trans-stilbene

5-Azacytidine
Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Nicotinamide
Inh 98-92-0 Pyridine-3-carboxylic acid amide

AS-8351
Inh 796-42-9 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone

UNC-0379
Inh 1620401-82-2 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine

GSK3326595
Inh 1616392-22-3 6-[(1-Acetylpiperidine-4-yl)amino]-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide

说明

Source: Produced by fermentation.
Appearance: Yellow Solid

限制

仅限研究用
状态

Solid

注意事项

Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects

注意事项

Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects

储存条件

-20 °C
Cha, St Louis, Tradewell, Gentil, Minotti, Jaffer, Chen, Rubenstein, Durham: "A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo." in: Cell stress & chaperones, Vol. 19, Issue 3, pp. 421-35, (2014) (PubMed).

Mori, Hitora, Nakamura, Yamagami, Horie, Nishimura, Yamamoto: "Hsp90 inhibitor induces autophagy and apoptosis in osteosarcoma cells." in: International journal of oncology, Vol. 46, Issue 1, pp. 47-54, (2014) (PubMed).
分子量

560.6

CAS-编号

30562-34-6